Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions

International Journal of Molecular Sciences

M. Olivia Noguez¹  Vanessa Marcelino¹  Hortensia Rodríguez³  Osnieski Martín³  Joel O. Martínez¹  Gabriel A. Arroyo¹  Francisco J. Pérez²  Margarita Suárez³ 

[1] Departamento de Ciencias Químicas, Facultad de Estudios Superiores Cuautitlán-UNAM, Estado de México, 54754, Mexico; E-Mails:;Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, D.F., 04510, Mexico; E-Mail:;Laboratorio de Síntesis Orgánica, Facultad de Química, Universidad de la Habana, 10400 Ciudad Habana, Cuba; E-Mails:

关键词: green approach;    infrared irradiation;    dihydropyridones;    multicomponent reaction;    Meldrum’s acid;   

DOI  :  10.3390/ijms12042641

来源: mdpi

【 摘 要 】

A green approach for the synthesis of a set of ten 4-aryl substituted-5-alcoxy carbonyl-6-methyl-3,4-dihydro-2(1H)-pyridones using Meldrum’s acid has been devised, the absence of solvent and the activation with infrared irradiation in addition to a multicomponent protocol are the main reaction conditions. The transformations proceeded with moderated yields (50–75%) with a reasonable reaction rate (3 h). It is worth noting that two novel molecules of the new class of the bis-3,4-dihydropyridones were also obtained. In addition, a comparison without the use of infrared irradiation was performed.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.