Photoredox-Catalyzed Giese Reactions: Decarboxylative Additions to Cyclic Vinylogous Amides and Esters

Molecules

Alexei Buevich¹  Qi Gao¹  Yu-Hong Lam²  Kevin Dykstra³  Jeffrey T. Kuethe⁴ 

[1] Analytical Research and Development, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA;Department of Computational and Structural Chemistry, Merck & Co., Inc., Rahway, NJ 07065, USA;Department of Medicinal Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, USA;Department of Process Research and Development, Merck & Co., Inc. Rahway, NJ 07065, USA;

关键词: photoredox;    dihydropyridones;    vinylogous amides and esters;   

DOI  :  10.3390/molecules27020417

来源: DOAJ

【 摘 要 】

An effective strategy has been developed for the photoredox-catalyzed decarboxylative addition of cyclic amino acids to both vinylogous amides and esters leading to uniquely substituted heterocycles. The additions take place exclusively trans to the substituent present on the dihydropyridone ring affording stereochemical control about the new carbon-carbon bond. These reactions are operationally simplistic and afford the desired products in good to excellent isolated yields.

【 授权许可】

Unknown