Wound healing and anti-inflammatory activities of Ceiba pentendra (l.) Gaertn

Pharmacological Research - Modern Chinese Medicine

Peter Akah¹  Stella Amarachi Ihim²  Chukwuemeka Sylvester Nworu²  Mercy Osifo³  Njideka Ani³ 

[1] Department of Science Laboratory Technology, University of Nigeria, Nsukka, Enugu 410001, Nigeria;Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu 410001, Nigeria;;Department of Pharmacology &

关键词: Antibacterial;    Anti-inflammatory;    Ceiba pentendra;    HPLC fingerprint;    Wound healing;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Traditionally, morphological parts of Ceiba pentandra have been reported as remedies against numerous diseases. On this basis, the wound healing and anti-inflammatory effects of the extract and fractions of Ceiba pentendra was investigated. Methodology: Preliminary qualitative phytochemical screening test was performed using HPLC fingerprint analysis. The extract (CPE) and fractions of graded solvent polarity: n-hexane (HXCP), ethylacetate (EACP) and Butanol (BNCP) were investigated for wound-healing potentials, using excision and incision models. Acute and chronic anti-inflammatory properties of C. pentendra were investigated using paw edema and cotton pellet models of inflammation in rats, respectively. Results: HPLC fingerprint analysis revealed the presence of Quercitrin, Apigenin and Catechin phytoconstituents. All the solvent fractions exhibited significant (p<0.05) higher rate of wound healing, contraction and epithelialization, with HXCP-30% fraction being the most active, with total wound healing occurring at the 16th day (100%). The wound breaking strength was significantly greater in groups treated with fractions HXCP-30% and BNCP-30%. In the cotton-pellets studies, the granuloma tissues formed in the extract treated groups were lower than those of the negative control. The result was significant (p<0.05) with CPE at 200 mg/kg and 400 mg/kg. In the paw edema studies, the extracts showed significant anti-inflammatory activities after 2 h with maximum percentage inhibition of 60.00% seen at the sixth hour at 400 mg CPE/kg dose level. Conclusion: The extract and fractions of Ceiba pentendra showed significant wound healing, anti-inflammatory and antibacterial activities which are relevant in explaining the traditional use of the plant in the treatment of wounds.

【 授权许可】

Unknown