Targeted Anti‐Tumor Immunotherapy Using Tumor Infiltrating Cells

Advanced Science

Lei Zhang¹  Fangfang Zhou²  Feng Xie²  Xiaoxue Zhou³  Fangwei Wang³  Jun Huang³  Jin Jin³  Long Zhang³  Linghui Zeng⁴  Yifan Xie⁴ 

[1] Department of Orthopaedic Surgery The Third Affiliated Hospital of Wenzhou Medical University Rui'an 325200 China;Institutes of Biology and Medical Science Soochow University Suzhou 215123 P. R. China;MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network Life Sciences Institute Zhejiang University Hangzhou 310058 China;School of Medicine Zhejiang University City College Hangzhou 310015 China;

关键词: anti‐tumor immunity;    anti‐tumor therapy;    B cells;    CD4+ T cells;    CD8+ T cells;    T‐cell exhaustion;   

DOI  :  10.1002/advs.202101672

来源: DOAJ

【 摘 要 】

Abstract In the tumor microenvironment, T cells, B cells, and many other cells play important and distinct roles in anti‐tumor immunotherapy. Although the immune checkpoint blockade and adoptive cell transfer can elicit durable clinical responses, only a few patients benefit from these therapies. Increased understanding of tumor‐infiltrating immune cells can provide novel therapies and drugs that induce a highly specific anti‐tumor immune response to certain groups of patients. Herein, the recent research progress on tumor‐infiltrating B cells and T cells, including CD8+ T cells, CD4+ T cells, and exhausted T cells and their role in anti‐tumor immunity, is summarized. Moreover, several anti‐tumor therapy approaches are discussed based on different immune cells and their prospects for future applications in cancer treatment.

【 授权许可】

Unknown