Multiple Sclerosis Journal – Experimental, Translational and Clinical | |
DNA methylation changes in CD4+ T cells isolated from multiple sclerosis patients on dimethyl fumarate | |
Vicki EMaltby1  | |
关键词: Multiple sclerosis; dimethyl fumarate; immunology; DNA methylation; relapsingâremitting; CD4+ T cells; tumour necrosis factor; | |
DOI : 10.1177/2055217318787826 | |
学科分类:医学(综合) | |
来源: Sage Journals | |
【 摘 要 】
BackgroundDimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood.ObjectiveTo investigate the effects of dimethyl fumarate on DNA methylation in the CD4+ T cells of multiple sclerosis patients.MethodsWe performed Illumina EPIC arrays to investigate the DNA methylation profiles of CD4+ T cells derived from multiple sclerosis patients before and after dimethyl fumarate treatment.ResultsTreatment with dimethyl fumarate resulted in 97% of differentially methylated positions showing hypermethylation. Four genes, SNORD1A, SHTN1, MZB1 and TNF had a differentially methylated region located within the transcriptional start site.ConclusionThis study investigates the effect of dimethyl fumarate on DNA methylation in multiple sclerosis patients.
【 授权许可】
CC BY-NC
【 预 览 】
Files | Size | Format | View |
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RO201910253562030ZK.pdf | 202KB | download |