DNA methylation changes in CD4+ T cells isolated from multiple sclerosis patients on dimethyl fumarate

Multiple Sclerosis Journal – Experimental, Translational and Clinical

Vicki EMaltby¹ 

关键词: Multiple sclerosis;    dimethyl fumarate;    immunology;    DNA methylation;    relapsing–remitting;    CD4+ T cells;    tumour necrosis factor;   

DOI  :  10.1177/2055217318787826

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

BackgroundDimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood.ObjectiveTo investigate the effects of dimethyl fumarate on DNA methylation in the CD4+ T cells of multiple sclerosis patients.MethodsWe performed Illumina EPIC arrays to investigate the DNA methylation profiles of CD4+ T cells derived from multiple sclerosis patients before and after dimethyl fumarate treatment.ResultsTreatment with dimethyl fumarate resulted in 97% of differentially methylated positions showing hypermethylation. Four genes, SNORD1A, SHTN1, MZB1 and TNF had a differentially methylated region located within the transcriptional start site.ConclusionThis study investigates the effect of dimethyl fumarate on DNA methylation in multiple sclerosis patients.

【 授权许可】

CC BY-NC