Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta

Marine Drugs

Bo-Wei Chen¹  Chiung-Yao Huang¹  Tzu-Zin Huang¹  Jyh-Horng Sheu¹  Tsong-Long Hwang²  Chang-Feng Dai³ 

[1] Department of Marine Biotechnology and Resources, National Sun Yat-sen University,Kaohsiung 804, Taiwan;Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan;Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan;

关键词: soft coral;    Cladiella hirsuta;    eunicellins: cytotoxic activity;    anti-inflammatory activity;   

DOI  :  10.3390/md12052446

来源: DOAJ

【 摘 要 】

New eunicellin-type hirsutalins N–R (1–5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1–7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1–7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

【 授权许可】

Unknown