Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta

Marine Drugs

卷:13

Bo-Wei Chen¹  Chiung-Yao Huang¹  Tzu-Zin Huang¹  Jyh-Horng Sheu¹  Chokkalingam Uvarani¹  Tsong-Long Hwang²  Chang-Feng Dai³  Jui-Hsin Su⁴  Ping-Jyun Sung⁴ 

[1] Department of Marine Biotechnology and Resources, National Sun Yat-sen University,Kaohsiung 804, Taiwan;

[2] Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center,Chang Gung University, Taoyuan 333, Taiwan;

[3] Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan;

[4] National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan;

关键词: soft coral;    Cladiella hirsuta;    eunicellins;    cytotoxic activity;    anti-inflammatory activity;   

DOI  :  10.3390/md13052757

来源: DOAJ

【 摘 要 】

Four new eunicellin-type hirsutalins S–V (1–4), along with a known compound (–)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1–5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1–5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/ CB-induced human neutrophils.

【 授权许可】

Unknown