Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta

Marine Drugs

Tzu-Zin Huang²  Bo-Wei Chen²  Chiung-Yao Huang²  Tsong-Long Hwang³  Chokkalingam Uvarani²  Chang-Feng Dai¹  Ping-Jyun Sung⁴  Jui-Hsin Su⁴  Jyh-Horng Sheu² 

[1] Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan; E-Mail:;Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails:;Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan; E-Mail:;National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; E-Mails:

关键词: soft coral;    Cladiella hirsuta;    eunicellins;    cytotoxic activity;    anti-inflammatory activity;   

DOI  :  10.3390/md13052757

来源: mdpi

【 摘 要 】

Four new eunicellin-type hirsutalins S–V (1–4), along with a known compound (–)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1–5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1–5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

【 授权许可】

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.