Klymollins T–X, Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Klyxum molle

Marine Drugs

Fang-Yu Chang¹  Fang-Jung Hsu¹  Chi-Jen Tai¹  Wen-Chi Wei²  Ning-Sun Yang² 

[1] Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails:;Agricultural Biotechnology Research Center, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan; E-Mail:

关键词: soft coral;    Klyxum molle;    eunicellin-based diterpenoids;    klymollins;    cytotoxic activity;    anti-inflammatory activity;   

DOI  :  10.3390/md12053060

来源: mdpi

【 摘 要 】

Five new eunicellin-based diterpenoids, klymollins T–X (1–5), along with two known compounds (6 and 7) have been isolated from the soft coral Klyxum molle. The structures of these new metabolites were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. Compound 5 was found to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. Furthermore, compounds 4 and 7 were shown to exhibit cytotoxicity against a limited panel of human cancer cell lines.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.