Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

Marine Drugs

Chi-Jen Tai³  Jui-Hsin Su⁴  Chiung-Yao Huang³  Ming-Shyan Huang¹  Zhi-Hong Wen³  Chang-Feng Dai² 

[1] Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan; E-Mail:;Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan; E-Mail:;Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails:;National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan; E-Mail:

关键词: eunicellin-based diterpenoids;    Cladiella krempfi;    cytotoxicity;    anti-inflammatory agents;   

DOI  :  10.3390/md11030788

来源: mdpi

【 摘 要 】

Five new eunicellin-based diterpenoids, krempfielins E–I (1–5) and seven known compounds (6–12) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. Metabolites 5, 6, 10 and 12 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 6 and 10 could potently inhibit the accumulation of the pro-inflammatory iNOS protein, and 6 and 12 could significantly reduce the expression of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.