Bioactive Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

Marine Drugs

Chi-Jen Tai²  Jui-Hsin Su⁴  Ming-Shyan Huang³  Zhi-Hong Wen²  Chang-Feng Dai¹ 

[1] Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan; E-Mail:;Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails:;Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan; E-Mail:;National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan; E-Mail:

关键词: soft coral;    Cladiella krempfi;    eunicellin-based diterpenoids;    krempfielins;    cytotoxic activity;    anti-inflammatory activity;   

DOI  :  10.3390/md9102036

来源: mdpi

【 摘 要 】

Four new eunicellin-based diterpenoids, krempfielins A–D (1–4), along with two known compounds (5 and 6) have been isolated from a soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compounds 5 and 6 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 2, 3, 5 and 6 were shown to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland