Sarcocrassocolides M–O, Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule

Marine Drugs

Wan-Yu Lin³  Yi Lu³  Bo-Wei Chen³  Chiung-Yao Huang³  Jui-Hsin Su¹  Zhi-Hong Wen³  Chang-Feng Dai²  Yao-Haur Kuo⁴ 

[1] National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan;Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan;Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan;National Research Institute of Chinese Medicine, Taipei 112, Taiwan;

关键词: soft coral;    Sarcophytoncrassocaule;    cytotoxic activity;    anti-inflammatory activity;   

DOI  :  10.3390/md10030617

来源: mdpi

【 摘 要 】

Three new cembranoids, sarcocrassocolides M–O (1–3), have been isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 1–3 were shown to exhibit moderate cytotoxicity toward a limited panel of cancer cell lines and display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.