Bioactive Cembranoids from the Dongsha Atoll Soft Coral Sarcophyton crassocaule

Marine Drugs

Wan-Yu Lin³  Yi Lu³  Jui-Hsin Su²  Zhi-Hong Wen³  Chang-Feng Dai⁴  Yao-Haur Kuo¹ 

[1] National Research Institute of Chinese Medicine, Taipei 112, Taiwan; E-Mail:;National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan; E-Mail:;Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails:;Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan; E-Mail:

关键词: soft coral;    Sarcophyton crassocaule;    cytotoxic activity;    anti-inflammatory activity;   

DOI  :  10.3390/md9060994

来源: mdpi

【 摘 要 】

Seven new cembranoids, sarcocrassocolides F–L (1–7), have been isolated from a soft coral Sarcophyton crassocaule. Their structures were determined by extensive spectroscopic analysis. Most new compounds exhibited significant cytotoxic activity against a limited panel of cancer cell lines, and the structure–activity relationship was studied. Compounds 1–7 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 4 was also found to effectively reduce the level of COX-2 protein.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.