Bioactive Cembranoids, Sarcocrassocolides P–R, from the Dongsha Atoll Soft Coral Sarcophyton crassocaule

Marine Drugs

Wan-Yu Lin²  Bo-Wei Chen²  Chiung-Yao Huang²  Zhi-Hong Wen²  Ping-Jyun Sung³  Jui-Hsin Su³  Chang-Feng Dai¹ 

[1] Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan; E-Mail:;Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails:;National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; E-Mails:

关键词: soft coral;    Sarcophyton crassocaule;    cytotoxic activity;    anti-inflammatory activity;   

DOI  :  10.3390/md12020840

来源: mdpi

【 摘 要 】

New cembranoids, sarcocrassocolides P–R (1–3) and four known compounds (4–7) were isolated from the soft coral Sarcophyton crassocaule. The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 3–5 and 7 were shown to exhibit cytotoxicity toward a limited panel of cancer cell lines and all compounds 1–7 displayed potent in vitro anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells by inhibiting the expression of inducible nitric oxide synthase (iNOS) protein. Compound 7 also showed significant activity in reducing the accumulation of cyclooxygenase-2 (COX-2) protein in the same macrophage cells.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.