Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta

Marine Drugs

Tzu-Zin Huang²  Bo-Wei Chen²  Chiung-Yao Huang²  Tsong-Long Hwang³  Chang-Feng Dai¹ 

[1] Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan; E-Mail:;Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails:;Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan; E-Mail:

关键词: soft coral;    Cladiella hirsuta;    eunicellins: cytotoxic activity;    anti-inflammatory activity;   

DOI  :  10.3390/md12052446

来源: mdpi

【 摘 要 】

New eunicellin-type hirsutalins N–R (1–5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1–7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1–7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.