Hydroxysafflor Yellow A Exerts Anti-Inflammatory Effects Mediated by SIRT1 in Lipopolysaccharide-Induced Microglia Activation

Frontiers in Pharmacology

Guowei Zhang¹  Xiude Qin²  Jinfang Li²  Haotao Zheng²  Juanjuan Chen²  Yu Liu²  Tianxiang Guan²  Haobin Cai²  Hong Xue²  Jinqiang Zhu³  Chuanpeng Li⁴ 

[1] Department of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Hebei University, Baoding, China;Encephalopathy Department, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China;Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China;The 1st Clinical Medical College, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China;

关键词: hydroxysafflor yellow A;    anti-inflammatory;    lipopolysaccharide;    SIRT1;    microglia;   

DOI  :  10.3389/fphar.2020.01315

来源: DOAJ

【 摘 要 】

Abnormal microglia activation causes sever neuroinflammation, contributing to the development of many diseases, yet the mechanism remains incompletely unknown. In current study, we identified that Hydroxysafflor yellow A (HYA), a chalcone glycoside derived from Carthamus tinctorius L effectively attenuates LPS-induced inflammation response in primary microglia via regulating the expression of inflammatory genes and remodeling the polarization of microglia. We also reported the effects of HYA on improving lipopolysaccharide (LPS)-stimulated mitochondrial dysfunction and oxidative stress for the first time. Interestingly, we found that HYA could serves as an effective SIRT1 activator. Deficiency of SIRT1 abrogates the protective effects of HYA against LPS-induced response. Overall, our data suggest HYA, a novel SIRT1 activator, could serve as an effective approach to treat LPS-induced neurodegenerative diseases.

【 授权许可】

Unknown