期刊论文详细信息
| Molbank | |
| 3-(4-Fluorophenyl)-N-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide Hydrochloride | |
| 关键词: spirocyclic; pyrazolone; reduction; <; em>; N<; /em>; -arylation; amide coupling; | |
| DOI : 10.3390/M771 | |
| 来源: DOAJ | |
【 摘 要 】
A simple and novel route for the synthesis of new spirocyclic propionamide derivative is developed. The present work involves N-arylation of pyrazolone (1) using copper(I) iodide catalyst followed by reduction to give amine (2). The coupling of 2 with 3-(4-fluorophenyl)propionic acid and deprotection of Boc group yields the title compound (3).
【 授权许可】
Unknown
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