3-(4-Fluorophenyl)-N-[4-(4-furan-2-yl-1-oxo-2,3,7-triazaspiro[4.5]dec-3-en-2-yl)phenyl]propionamide Hydrochloride

Molbank

Rajagopalan Srinivasan¹  Badiadka Narayana¹  Seranthimata Samshuddin¹ 

[1] ¹Department of Studies in Chemistry, Mangalore University, Mangalagangotri-574 199, Karnataka, India ²Aurigene Discovery Technologies Limited, Electronics city, Phase-II, Bangalore-560 100, Karnataka, India ³Research Department of Chemistry, P. A College of Engineering, Nadupadavu, Mangalore 574153, Karnataka, India

关键词: spirocyclic;    pyrazolone;    reduction;    N-arylation;    amide coupling;   

DOI  :  10.3390/M771

来源: mdpi

【 摘 要 】

A simple and novel route for the synthesis of new spirocyclic propionamide derivative is developed. The present work involves N-arylation of pyrazolone (1) using copper(I) iodide catalyst followed by reduction to give amine (2). The coupling of 2 with 3-(4-fluorophenyl)propionic acid and deprotection of Boc group yields the title compound (3).

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.