4-[5-(3,5-Difluorophenyl)furan-2-yl]-2,3,7-triazaspiro[4.5]dec-3-en-1-one Hydrochloride

Molbank

Rajagopalan Srinivasan¹  Badiadka Narayana¹  Seranthimata Samshuddin¹ 

[1] ¹Department of Studies in Chemistry, Mangalore University, Mangalagangotri-574 199, Karnataka, India ²Aurigene Discovery Technologies Limited, Electronics city, Phase-II, Bangalore-560 100, Karnataka, India ³Research Department of Chemistry, P. A College of Engineering, Nadupadavu, Mangalore 574153, Karnataka, India

关键词: spirocyclic;    pyrazolone;    Suzuki coupling;    ethyl nipecotate;   

DOI  :  10.3390/M773

来源: mdpi

【 摘 要 】

A novel route for the synthesis of new spirocyclic derivative is developed. The present work involves the synthesis of title compound 3 by Suzuki coupling of 3,5-difluorophenyl boronic acid with tert-butyl 1-(5-bromofuran-2-yl)-4-oxo-2,3,7-triazaspiro[4.5]dec-1-ene-7-carboxylate (2), which in turn prepared from the ethyl nipecotate (1). Newly prepared spirocyclic derivative (3) is characterized by IR, NMR and mass spectral data.

【 授权许可】

CC BY   
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