Cell based therapeutic approach in vascular surgery: application and review

Open Medicine

Giuliani Antonio¹  Surfaro Giuseppe²  Serra Raffaele³  Paccone Marianna⁴  Paccone Andrea⁴  Tafuri Domenico⁵  Rocca Aldo⁶  Amato Bruno⁷  Amato Maurizo⁷  Compagna Rita⁷  Zamboli Anna Ginevra Immacolata⁸ 

[1] A.O.R.N. A. Cardarelli Hepatobiliary and Liver Transplatation Center, Naples, Italy;Antonio Cardarelli Hospital, General Surgery Unit, Campobasso, Italy;Department of Medical and Surgical Sciences, University of Catanzaro, Catanzaro, Italy;Department of Medicine and Health Sciences Vincenzo Tiberio, University of Molise, Campobasso, Italy;Department of Sport Sciences and Wellness, University of Naples “Parthenope”, Naples, Italy;Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy. Via Sergio Pansini, 80131Naples, Italy;Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy;Santa Maria della Pietà Hospital, Nola, Italy;

关键词: multipotent stem cells;    vascular surgery;    cell-based therapy;    vascular progenitors;    arterial aneurysms;    peripheral arterial obstructive disease;   

DOI  :  10.1515/med-2017-0045

来源: DOAJ

【 摘 要 】

Multipotent stem cells - such as mesenchymal stem/stromal cells and stem cells derived from different sources like vascular wall are intensely studied to try to rapidly translate their discovered features from bench to bedside. Vascular wall resident stem cells recruitment, differentiation, survival, proliferation, growth factor production, and signaling pathways transduced were analyzed. We studied biological properties of vascular resident stem cells and explored the relationship from several factors as Matrix Metalloproteinases (MMPs) and regulations of biological, translational and clinical features of these cells. In this review we described a translational and clinical approach to Adult Vascular Wall Resident Multipotent Vascular Stem Cells (VW-SCs) and reported their involvement in alternative clinical approach as cells based therapy in vascular disease like arterial aneurysms or peripheral arterial obstructive disease.

【 授权许可】

Unknown