Frequency of anaplastic lymphoma kinase rearrangements in Moroccan patients with non small cell lung cancer: a multi-institutional national retrospective study

BMC Cancer

Mohamed Lemine Sow¹  Amina Mestari²  Lamia Jabri³  Lamia Gamra⁴  Fouad Kettani⁵  Hind El yacoubi⁶  Hassan Errihani⁶  Ibrahim Elghissassi⁶ 

[1] Department of Medical Oncology, National Institute of Oncology;Department of Pathology, Agdal Pathology Center;Department of Pathology, Casapath Pathology Center;Department of Pathology, Hassan Pathology Center;Department of Pathology, Nations-Unies Pathology Center;Research and investigation in medical oncology Moroccan group, Faculty of medicine and pharmacy, Mohammed V University;

关键词: Anaplastic lymphoma kinase rearrangement;    Non small cell lung cancer;    Morroco;    Frequency;   

DOI  :  10.1186/s12885-020-06973-4

来源: DOAJ

【 摘 要 】

Abstract Background Anaplastic lymphoma kinase (ALK) rearrangement is a predictive factor of response to ALK inhibitors in non small cell lung cancer (NSCLC). The prevalence of ALK rearrangements is well known in Whites and Asians. However, data identifying the frequency of this rearrangement in Moroccan and North African population are lacking. The objective of this study is to report the frequency of ALK rearrangement in a group of Moroccan patients with NSCLC. Methods A retrospective study was performed enrolling 120 Moroccan patients with NSCLC whose biopsy samples were tested for ALK rearrangement in order to identify the frequency of ALK rearrangement and its potential association with selected variables. The ALK testing was established using fluorescent in situ hybridization (FISH) or immunohistochemistry (IHC). Results The frequency of ALK rearrangement was 4.2% (5/120). All positive cases were males with advanced adenocarcinoma. ALK rearrangements prevalence was significantly higher in older patients. Conclusions The frequency of ALK rearrangements among the Moroccan population tends to correlate with the average frequency reported worldwide, with some specific features. Further prospective studies with larger patients’ numbers are needed to verify these findings.

【 授权许可】

Unknown