Humoral immune response induced with dengue virus-like particles serotypes 1 and 4 produced in silkworm

AMB Express

Sabar Pambudi¹  Enoch Y. Park²  Doddy Irawan Setyo Utomo² 

[1] Center of Pharmaceutical and Medical Technology, National Research and Innovation Agency (BRIN), Jl. Kawasan Puspiptek, Gedung I LAPTIAB;Laboratory of Biotechnology, Department of Bioscience, Graduate School of Science and Technology, Shizuoka University;

关键词: Dengue virus;    Capsid;    Premembrane;    Envelope;    Dengue virus-like particle;    Silkworm;   

DOI  :  10.1186/s13568-022-01353-6

来源: DOAJ

【 摘 要 】

Highlights Dengue virus-like particles for serotype 1 and serotype 4 (DENV-LPs/1 and DENV-LPs/4) were produced in silkworm. Heparin-binding assay by ELISA and ITC showed that DENV-LPs/1 and DENV-LPs/4 contain Envelope Domain III. DENV-LPs/1 and DENV-LPs/4 showed affinity to sera from human dengue patients and immunized mice.

【 授权许可】

Unknown