Immunomodulatory Effects of Phosphorylated Radix Cyathulae officinalis Polysaccharides in Immunosuppressed Mice

Molecules

Haibo Feng¹  Jie Yang²  Dongkun Chai²  Lang Lin²  Yunjie Liu²  Jing Fan³ 

[1] College of Life Science and Technology, Southwest Minzu University, Chengdu, Sichuan 6100041, China;Department of Veterinary Medicine, Southwest University, Rongchang, Chongqing 402460, China;Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu, Sichuan 610051, China;

关键词: radix cyathula officinalis kuan polysaccharide;    phosphorylation modification;    polysaccharide;    immunosuppressed mice;   

DOI  :  10.3390/molecules24224150

来源: DOAJ

【 摘 要 】

This research aimed to investigate the immunomodulatory effects of phosphorylated Radix Cyathulae officinalis Kuan polysaccharides (pRCPS) in immunosuppressed mice, improving their cellular and humoral immune function. Our results showed that pRCPS increased serum immunoglobulin (IgG, IgA, IgM) concentrations significantly, enhanced splenocyte proliferation, and the thymus and spleen indices. pRCPS also promoted phagocytosis in peritoneal macrophages and enhanced cytokine (IFN-γ, IL-2, -4, -5, -6, and -10) serum levels. Importantly, pRCPS increased the proportions of selected T cell subpopulations (CD3⁺, CD4⁺, and the CD4⁺ to CD8⁺ ratio). Our results revealed that phosphorylation of the polysaccharides promoted their immune-enhancing effects. Thus, pRCPS can enhance cellular and humoral immunity and could be used as an immune-enhancing agent to overcome cyclophosphamide (CY)-induced immunosuppression.

【 授权许可】

Unknown