Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp

Molecules

Yang Yi¹  Sen-Tai Liao¹  Ming-Wei Zhang¹  Rui-Fen Zhang¹  Yuan-Yuan Deng¹  Bao Yang¹ 

[1]¹Key Laboratory of Functional Food, Ministry of Agriculture, Bio-Tech Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China[2] height:6px

[3]"> ²College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China[4] height:6px

[5]"> ³South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China

关键词: longan pulp;    polysaccharide-protein complex;    immunomodulatory activity;    immunosuppressed mice;    cyclophosphamide;   

DOI  :  10.3390/molecules161210324

来源: mdpi

【 摘 要 】

The immunomodulatory function of longan pulp polysaccharide-protein complex (LP3) was investigated in immunosuppressed mice models. Compared with the model control, peroral administration of 100 mgkg⁻¹d⁻¹ LP3 could significantly increase/enhance antibody production against chicken red blood cell (CRBC), concanavalin A (ConA)-induced splenocyte proliferation, macrophage phagocytosis, NK cell cytotoxicity against YAC-1 lymphoma cell, and interferon-gamma (INF-γ) and interleukin-2 (IL-2) secretion in serum (P < 0.05). The immunomodulatory effects, except for those on splenocytes and macrophages (P > 0.05), were also observed in mice administered with 50 or 200 mgkg⁻¹d⁻¹ LP3 (P < 0.05). The beneficial effects of 50–200 mgkg⁻¹d⁻¹ LP3 were comparable to those of 50 mgkg⁻¹d⁻¹ ganoderan. The strong immunomodulatory activity of LP3 confirmed its good potential as an immunotherapeutic adjuvant.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.