Genetic variability of the VP1 gene of BK and JC polyomaviruses in HIV-infected patients

Medicinski Podmladak

Karalić Danijela¹  Lazarević Ivana¹ 

[1] University of Belgrade, Faculty of Medicine - Institute of Microbiology and Immunology, Belgrade, Serbia;

关键词: BKV;    JCV;    HIV;    mutations;    VP1;   

DOI  :  10.5937/medpodm1502031K

来源: DOAJ

【 摘 要 】

Human polyomaviruses, BK virus (BKV) and JC virus (JCV), are world widely distributed in human population. After primary infection, BKV and JCV establish latency in kidneys and upper part of urinary tract. In seropositive healthy individuals asymptomatic reactivation of both viruses occurs in in 0.5-20%. On the other hand, reactivation of these viruses in imunosuppressed patients, primarily in patients with T cell immunodeficiency, can lead to development of polyomavirus-associated diseases. Some of these diseases such as progressive multifocal leukoencephalopathy (PML), polyomavirus-induced nephropathy (PVN), hemorrhagic cystitis (HC) are life-threatening diseases with high mortality and morbidity rate. However, they do not affect all immunosuppressed patients, suggesting that other factors, such as genetic variability of BKV and JCV, can contribute to their occurrence. Immunosuppression leads to increased levels of replication of both viruses. Increased levels of replication are associated with higher incidence of mutations in the VP1 gene. Mutations, especially those located in outer loops, may lead to changed tropism and generation of more aggressive variants of BKV and JCV. This review is focused on clinical significance of BK and JC virus infection in immunosuppressed patients, especially in HIV-infected, and sequence changes in the VP1 gene that can contribute to selection of more virulent variants of BKV and JCV via adaptive evolution.

【 授权许可】

Unknown