High Frequency of JCV DNA Detection in Prostate Cancer Tissues

Cancer Genomics - Proteomics

STEFANO SALCICCIA³  ALESSANDRO SCIARRA³  VINCENZO GENTILE³  VALERIA PIETROPAOLO²  MONICA MISCHITELLI⁴  ANNA BELLIZZI¹  DONATELLA MARIA RODIO⁴  ELENA ANZIVINO⁴ 

[1] epartment of Public Health and Infectious Diseases, Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, Rome, Italyepartment of Neuroscience, Temple University School of Medicine, Philadelphia, PA, U.S.A.epartment of Public Health and Infectious Diseases, Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, Rome, Italyepartment of Public Health and Infectious Diseases, Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, Rome, Italyepartment of Neuroscience, Temple University School of Medicine, Philadelphia, PA, U.S.A.epartment of Neuroscience, Temple University School of Medicine, Philadelphia, PA, U.S.A.epartment of Public Health and Infectious Diseases, Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, Rome, Italyepartment of Neuroscience, Temple University School of Medicine, Philadelphia, PA, U.S.A.;epartment of Health Sciences and Infectious Diseases, Sapienza University, Rome, Italybarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, U.S.A.epartment of Health Sciences and Infectious Diseases, Sapienza University, Rome, Italyepartment of Health Sciences and Infectious Diseases, Sapienza University, Rome, Italybarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, U.S.A.barro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, U.S.A.epartment of Health Sciences and Infectious Diseases, Sapienza University, Rome, Italybarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, U.S.A.;epartment of Obstretics, Gynecology and Urological Sciences, Sapienza University, Rome, Italyepartment of Obstretics, Gynecology and Urological Sciences, Sapienza University, Rome, Italyepartment of Obstretics, Gynecology and Urological Sciences, Sapienza University, Rome, Italy;epartment of Health Sciences and Infectious Diseases, Sapienza University, Rome, Italyepartment of Health Sciences and Infectious Diseases, Sapienza University, Rome, Italyepartment of Health Sciences and Infectious Diseases, Sapienza University, Rome, Italy

关键词: Prostate cancer;    JCV;    BKV;    NCCR;    sequence analysis;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Background: Prostate cancer (PC) represents the most frequently diagnosed cancer in men. Exposure to infectious agents has been considered to induce prostatic inflammation and cancerous transformation. Controversial data exist concerning the role of the human polyomaviruses BK (BKV) and JC (JCV) in PC etiology. Therefore, a possible association between these polyomaviruses and PC was investigated. Materials and Methods: Urine, blood and fresh prostatic tissue specimens were collected from 26 patients with PC. The presence of BKV and JCV, the possible non-coding control region (NCCR) variations and the genotyping analysis of viral protein 1 (VP1) of both viruses were assessed. Results: Data showed a preferential viral re-activation in the urinary compartment and a statistically significant prevalence of JC viruria and of BKV in PC tissues. A BKV DDP-like NCCR sequence was isolated in two patients, whereas JCV NCCR was consistently of an archetypal structural organization. A prevalence of the European genotypes was observed for both viruses. Conclusion: Our data demonstrated the presence of JCV DNA in 14/24 (58.3%) cancerous prostatic tissue specimens, confirming the results obtained in a previous study, in which JCV has been defined as common inhabitant of the prostate, and opening the discussion about its potential role in PC.

【 授权许可】

Unknown