Green synthesis of multifunctional silver nanoparticles using quercetin and their therapeutic potential

Nanomedicine Research Journal

Pourya Biparva¹  Mostafa Kardan²  Saeedeh Maghsoodloo³  Mahsa Mohammadyan³  Mohammad Ali Ebrahimzadeh³  Shahram Eslami³  Shirin Tavakoli⁴  Alireza Rafiei⁵  Hamidreza Mohammadi⁶ 

[1] Department of Basic Sciences, Sari University of Agricultural Sciences and Natural Resources, Sari, Iran;Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran;Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran;Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran;Molecular and Cell Biology Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran;Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran;

关键词: quercetin;    green synthesis;    silver nanoparticle;    antioxidant;    anticancer;    antifungal;   

DOI  :  10.22034/nmrj.2020.02.008

来源: DOAJ

【 摘 要 】

Objective(s): Active species used in bio-chemical for synthesizing nanoparticles is poly phenolic compounds. The ability of flavonoids (e.g. quercetin) to dissolve in water is low and the production of metallic nanoparticles from them in the aqueous medium is hard. Previous studies recommend that quercetin was not capable of reducing Ag+ to Ag0. The current research aimed at synthesizing quercetin-mediated silver nanoparticles (Q-AgNPs) and evaluate the antioxidant and anticancer activities of Q-AgNPs in vitro. Methods: The green synthesis of Q-AgNPs in an aqueous medium has been demonstrated. The resultant nanoparticles were characterized by several analytical techniques of imaging and spectroscopic. The improved antioxidant activity of Q-AgNPs (DPPH and nitric oxide scavenging and iron chelating assay) was determined by the colorimetric method. Possible biomedical applications such as antioxidant and anticancer activities of Q-AgNPs have been assessed. Results: The DPPH and nitric oxide radical scavenging activity of Q-AgNPs was found to be (IC50=46.47±1.79 and 30.64±3.18μg/mL, respectively). Q-AgNPs exhibited better iron chelating activity than standard EDTA (IC50=3.12 ±0.44μg/mL). Significant anticancer activity of Q-AgNPs (IC50=57.42μg/mL) was found against HepG2 cell lines after 24-hour exposure. Furthermore, the antifungal activity (MIC = 4, 8 and > 64 μg/mL) was found against Candida krusei, Candida parapsilosis and Aspergillus fumigatus, respectively. Conclusions: The present method is a competitive option to produce multifunctional nanoscale hybrid materials with higher efficiency and using natural sources for diverse biomedical applications such as antioxidant and anticancer activities.

【 授权许可】

Unknown