Polymers | |
One-Pot and Green Preparation of Phyllanthus emblica Extract/Silver Nanoparticles/Polyvinylpyrrolidone Spray-On Dressing | |
Whijitra Suvandee1  Decha Dechtrirat1  Veerawat Teeranachaideekul2  Laemthong Chuenchom3  Patcharakamon Nooeaid4  Arthit Makarasen5  Supanna Techasakul5  Nutjaree Jeenduang6  | |
[1] Department of Materials Science, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand;Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand;Division of Physical Science and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Songkhla 90110, Thailand;Division of Polymer Materials Technology, Faculty of Agricultural Product Innovation and Technology, Srinakharinwirot University, Nakhon-Nayok 26120, Thailand;Laboratory of Organic Synthesis, Chulabhorn Research Institute, Bangkok 10210, Thailand;School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand; | |
关键词: green synthesis; spray-on dressing; silver nanoparticle; wound healing; Phyllanthus emblica; | |
DOI : 10.3390/polym14112205 | |
来源: DOAJ |
【 摘 要 】
A spray-on wound dressing has many benefits, including easy and quick administration to broad and uneven wounds, better interface with the wound site, adhesion without additional dressing, and multiple applications in a portable package. By limiting direct contact with the wound site, such a design can prevent wound damage during treatment. This study revealed a simple, one-pot synthesis of spray-on wound dressing relying on polyvinylpyrrolidone solution incorporating silver nanoparticles as a broad-spectrum antibacterial agent and wound-healing antioxidant Phyllanthus emblica extract. Silver nanoparticles were synthesized in situ using Phyllanthus emblica extract as a biogenic reducing agent. Polyvinylpyrrolidone was employed as a film-forming agent to create an adhesive hydrogel-based dressing matrix to provide moisture and establish a shielding barrier for the wound bed as well as to regulate the release of fruit extract. In vitro tests revealed that the produced dressing film had a controlled release of the fruit extract, high antioxidant activity, and a good antibacterial action against S. aureus, P. aeruginosa, E. coli, and MRSA. Additionally, a biocompatibility study has shown that both human fibroblasts and keratinocytes are unaffected by the dressing film. Based on established findings, the current spray-on solution might be a potential option for antibacterial wound dressing.
【 授权许可】
Unknown