Biodegradable metals for bone defect repair: A systematic review and meta-analysis based on animal studies

Bioactive Materials

Yanbiao Jiang¹  Jiazhen Zhang²  Bao Zhai²  Bin Ma²  Bin Liu²  Maobo Cheng²  Xinli Shi²  Yajuan Guo²  Mingyue Jiao³  Zhizhong Shang³  Bing Zhao³  Wenbo Liu³ 

[1] Corresponding author. Center for Medical Device Evaluation, National Medical Products Administration, Beijing, 100081, PR China.;Center for Medical Device Evaluation, National Medical Products Administration, Beijing, 100081, PR China;Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, PR China;

关键词: Biodegradable metals;    Bone defect repair;    Animal model;    Systematic review and meta-analysis;    Regulatory science;    Safety and effectiveness;   

DOI  :  

来源: DOAJ

【 摘 要 】

Biodegradable metals are promising candidates for bone defect repair. With an evidence-based approach, this study investigated and analyzed the performance and degradation properties of biodegradable metals in animal models for bone defect repair to explore their potential clinical translation. Animal studies on bone defect repair with biodegradable metals in comparison with other traditional biomaterials were reviewed. Data was carefully collected after identification of population, intervention, comparison, outcome, and study design (PICOS), and following the inclusion criteria of biodegradable metals in animal studies. 30 publications on pure Mg, Mg alloys, pure Zn and Zn alloys were finally included after extraction from a collected database of 2543 publications. A qualitative systematic review and a quantitative meta-analysis were performed. Given the heterogeneity in animal model, anatomical site and critical size defect (CSD), biodegradable metals exhibited mixed effects on bone defect repair and degradation in animal studies in comparison with traditional non-degradable metals, biodegradable polymers, bioceramics, and autogenous bone grafts. The results indicated that there were limitations in the experimental design of the included studies, and quality of the evidence presented by the studies was very low. To enhance clinical translation of biodegradable metals, evidence-based research with data validity is needed. Future studies should adopt standardized experimental protocols in investigating the effects of biodegradable metals on bone defect repair with animal models.

【 授权许可】

Unknown