Recent advances in 3D printing of biodegradable metals for orthopaedic applications

Journal of Biological Engineering

Review

Xiaogang Huang¹  Wenqing Liang¹  Hengjian Zhang¹  Jiayi Zhao¹  Juqin Bai¹  Hengguo Long¹  Wenyi Ming¹  Hongwei Zhang¹  Chao Zhou²  Chanyi Jiang³  Bo Jiang⁴ 

[1] Department of Orthopaedics, Zhoushan Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, 355 Xinqiao Road, Dinghai District, 316000, Zhoushan, Zhejiang Province, China;Department of Orthopedics, Zhoushan Guanghua Hospital, 316000, Zhoushan, China;Department of Orthopedics, Zhoushan Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, 316000, Zhoushan, Zhejiang Province, P.R. China;Rehabilitation Department, Zhoushan Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University, 316000, Zhoushan, China;

关键词: Biodegradable metals;    3D printing;    Bioactive materials;    Orthopaedic therapies;    Polymer composites;   

DOI  :  10.1186/s13036-023-00371-7

 received in 2023-06-01, accepted in 2023-07-31,  发布年份 2023

来源: Springer

【 摘 要 】

The use of biodegradable polymers for treating bone-related diseases has become a focal point in the field of biomedicine. Recent advancements in material technology have expanded the range of materials suitable for orthopaedic implants. Three-dimensional (3D) printing technology has become prevalent in healthcare, and while organ printing is still in its early stages and faces ethical and technical hurdles, 3D printing is capable of creating 3D structures that are supportive and controllable. The technique has shown promise in fields such as tissue engineering and regenerative medicine, and new innovations in cell and bio-printing and printing materials have expanded its possibilities. In clinical settings, 3D printing of biodegradable metals is mainly used in orthopedics and stomatology. 3D-printed patient-specific osteotomy instruments, orthopedic implants, and dental implants have been approved by the US FDA for clinical use. Metals are often used to provide support for hard tissue and prevent complications. Currently, 70–80% of clinically used implants are made from niobium, tantalum, nitinol, titanium alloys, cobalt-chromium alloys, and stainless steels. However, there has been increasing interest in biodegradable metals such as magnesium, calcium, zinc, and iron, with numerous recent findings. The advantages of 3D printing, such as low manufacturing costs, complex geometry capabilities, and short fabrication periods, have led to widespread adoption in academia and industry. 3D printing of metals with controllable structures represents a cutting-edge technology for developing metallic implants for biomedical applications. This review explores existing biomaterials used in 3D printing-based orthopedics as well as biodegradable metals and their applications in developing metallic medical implants and devices. The challenges and future directions of this technology are also discussed.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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