A 3D-Printed Modular Microreservoir for Drug Delivery

Micromachines

Robert D. Frisina¹  Joseph P. Walton¹  Meng-Chun Hsu²  Nuzhet N. Ahamed²  Farzad Forouzandeh²  David A. Borkholder² 

[1] Department of Chemical & Biomedical Engineering, Global Center for Hearing & Speech Research, University of South Florida, Tampa, FL 33612, USA;Microsystems Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA;

关键词: modular microfluidics;    drug delivery;    microreservoir;    implantable;    transdermal;    3D-printing;   

DOI  :  10.3390/mi11070648

来源: DOAJ

【 摘 要 】

Reservoir-based drug delivery microsystems have enabled novel and effective drug delivery concepts in recent decades. These systems typically comprise integrated storing and pumping components. Here we present a stand-alone, modular, thin, scalable, and refillable microreservoir platform as a storing component of these microsystems for implantable and transdermal drug delivery. Three microreservoir capacities (1, 10, and 100 µL) were fabricated with 3 mm overall thickness using stereolithography 3D-printing technology, enabling the fabrication of the device structure comprising a storing area and a refill port. A thin, preformed dome-shaped storing membrane was created by the deposition of parylene-C over a polyethylene glycol sacrificial layer, creating a force-free membrane that causes zero forward flow and insignificant backward flow (2% of total volume) due to membrane force. A septum pre-compression concept was introduced that enabled the realization of a 1-mm-thick septa capable of ~65000 leak-free refill punctures under 100 kPa backpressure. The force-free storing membrane enables using normally-open micropumps for drug delivery, and potentially improves the efficiency and precision of normally-closed micropumps. The ultra-thin septum reduces the thickness of refillable drug delivery devices, and is capable of thousands of leak-free refills. This modular and scalable device can be used for drug delivery in different laboratory animals and humans, as a sampling device, and for lab-on-a-chip and point-of-care diagnostics applications.

【 授权许可】

Unknown