Temperature Sensing in Modular Microfluidic Architectures

Micromachines

Anoop Tembhekar¹  Bryant Thompson¹  Krisna C. Bhargava²  Noah Malmstadt² 

[1] Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA;Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089, USA;

关键词: modular microfluidics;    thermal sensor;    flow sensor;   

DOI  :  10.3390/mi7010011

来源: DOAJ

【 摘 要 】

A discrete microfluidic element with integrated thermal sensor was fabricated and demonstrated as an effective probe for process monitoring and prototyping. Elements were constructed using stereolithography and market-available glass-bodied thermistors within the modular, standardized framework of previous discrete microfluidic elements demonstrated in the literature. Flow rate-dependent response due to sensor self-heating and microchannel heating and cooling was characterized and shown to be linear in typical laboratory conditions. An acid-base neutralization reaction was performed in a continuous flow setting to demonstrate applicability in process management: the ratio of solution flow rates was varied to locate the equivalence point in a titration, closely matching expected results. This element potentially enables complex, three-dimensional microfluidic architectures with real-time temperature feedback and flow rate sensing, without application specificity or restriction to planar channel routing formats.

【 授权许可】

Unknown