Implantable coaxial nanocomposite biofibers for local chemo‐photothermal combinational cancer therapy

Nano Select

Hanghang Liu¹  Zhen Li¹  Kara L. Vine²  Javad Foroughi²  Sepehr Talebian³ 

[1] Center for Molecular Imaging and Nuclear Medicine State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD‐X) Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University Suzhou P. R. China;Illawarra Health and Medical Research Institute University of Wollongong Wollongong NSW Australia;Intelligent Polymer Research Institute University of Wollongong NSW Australia;

关键词: chemo‐photothermal cancer therapy;    drug delivery;    hydrogel fibers;    implantable;    nanocomposite polymer;   

DOI  :  10.1002/nano.202100124

来源: DOAJ

【 摘 要 】

Abstract Multi‐therapy strategies that coexist in a single system for cancer therapy has a great clinical application potential. In this paper, with the aim of establishing a suitable implantable platform for multimodal chemo‐photothermal cancer therapy, we have fabricated a coaxial composite hydrogel fiber that facilitated prolonged release of Doxorubicin from core. Fibers also served as NIR‐absorbing mediators, via incorporation of Cu2‐xSe nanoparticles in the shell, to facilitate chemo‐photothermal combinational effects. In vitro experiments exhibited excellent photo‐thermal properties of the fibers and exceptional cancer cell‐killing efficiency. Remarkably, in vivo antitumor experiments showed that Doxorubicin‐loaded coaxial hydrogel fibers containing Cu2‐xSe nanoparticles had outstanding antitumor efficacy, compared with chemotherapy or photothermal application alone. Overall, the coaxial composite hydrogel fibers provided a safe and efficacious implantable platform for multimodal chemo‐photothermal therapy that could potentially be used to control the progression of cancer locally at the tumor site.

【 授权许可】

Unknown