Bioresorbable intracranial pressure sensors for clinical applications

Bioresorbable, implantable sensors, intracranial pressure

Shin, Jiho

关键词: Bioresorbable, implantable sensors, intracranial pressure;   

Others  :  https://www.ideals.illinois.edu/bitstream/handle/2142/101344/SHIN-DISSERTATION-2018.pdf?sequence=1&isAllowed=y

美国|英语

来源: The Illinois Digital Environment for Access to Learning and Scholarship

【 摘 要 】

Monitoring pressure in organ systems such as the brain, eye, and blood vessels form an essential diagnostic basis for assessment of patient health and progression of diseases such as traumatic brain injury, hydrocephalus, glaucoma, and hypertension. Conventional sensor technologies designed for precise, continuous monitoring of pressure are available in the form of accurate, implantable devices that must be surgically extracted after use, the procedures of which are costly and can expose the patient to significant pain and risks for complications. These permanent electronic hardware may also act as a nidus for infection, via biofilm formation along percutaneous wires, and provoke immune-mediated inflammatory responses. Here, we report materials, device structures, and fabrication strategies for bioresorbable pressure sensors, in which all of the constituent materials dissolve in biofluids over well-defined periods of time, with biologically benign end products, that can address these disadvantages.