Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside

International Journal of Molecular Sciences

Elizabeth Clarke¹  Haiyan Lin²  Lara Bereza-Malcolm²  Ruilong Zhao²  Meilang Xue²  Christopher John Jackson² 

[1] Murray Maxwell Biomechanics Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Northern Clinical School, University of Sydney, Sydney, NSW 2065, Australia;Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Northern Clinical School, University of Sydney, Sydney, NSW 2065, Australia;

关键词: activated protein C;    wound healing;    cytoprotection;    cell culture;    animal models;    clinical trials;   

DOI  :  10.3390/ijms20040903

来源: DOAJ

【 摘 要 】

Independent of its well-known anticoagulation effects, activated protein C (APC) exhibits pleiotropic cytoprotective properties. These include anti-inflammatory actions, anti-apoptosis, and endothelial and epithelial barrier stabilisation. Such beneficial effects have made APC an attractive target of research in a plethora of physiological and pathophysiological processes. Of note, the past decade or so has seen the emergence of its roles in cutaneous wound healing—a complex process involving inflammation, proliferation and remodelling. This review will highlight APC’s functions and mechanisms, and detail its pre-clinical and clinical studies on cutaneous wound healing.

【 授权许可】

Unknown