Palifermin for the protection and regeneration of epithelial tissues following injury: new findings in basic research and pre‐clinical models

Journal of Cellular and Molecular Medicine

Paul W. Finch¹  Lawrence J. Mark Cross²  Daniel F. McAuley² 

[1] Croton-on-Hudson, NY, USA;Centre for Infection and Immunity, The Queen's University of Belfast, Belfast, N Ireland, UK

关键词: palifermin;    KGF;    FGFR2b;    cytoprotection;    epithelial repair;    GVHD;    immune reconstitution;    mucositis;    pericardial adhesions;    pre‐synaptic organizing molecules;    pulmonary injury;    regeneration;    urothelium;    wound healing;   

DOI  :  10.1111/jcmm.12091

来源: Wiley

【 摘 要 】

Abstract

Keratinocyte growth factor (KGF) is a paracrine-acting epithelial mitogen produced by cells of mesenchymal origin, that plays an important role in protecting and repairing epithelial tissues. Pre-clinical data initially demonstrated that a recombinant truncated KGF (palifermin) could reduce gastrointestinal injury and mortality resulting from a variety of toxic exposures. Furthermore, the use of palifermin in patients with hematological malignancies reduced the incidence and duration of severe oral mucositis experienced after intensive chemoradiotherapy. Based upon these findings, as well as the observation that KGF receptors are expressed in many, if not all, epithelial tissues, pre-clinical studies have been conducted to determine the efficacy of palifermin in protecting different epithelial tissues from toxic injury in an attempt to model various clinical situations in which it might prove to be of benefit in limiting tissue damage. In this article, we review these studies to provide the pre-clinical background for clinical trials that are described in the accompanying article and the rationale for additional clinical applications of palifermin.

【 授权许可】

CC BY   
© 2013 The Authors. Journal of Cellular and Molecular Medicine Published by Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.