Emerging Roles of Fibroblast Growth Factor 10 in Cancer

Frontiers in Genetics

关键词: FGF10;    FGFR2;    FGFR2b;    FGFR1;    FGFR1b;    cancer;   

DOI  :  10.3389/fgene.2018.00499

来源: DOAJ

【 摘 要 】

Whilst cross-talk between stroma and epithelium is critical for tissue development and homeostasis, aberrant paracrine stimulation can result in neoplastic transformation. Chronic stimulation of epithelial cells with paracrine Fibroblast Growth Factor 10 (FGF10) has been implicated in multiple cancers, including breast, prostate and pancreatic ductal adenocarcinoma. Here, we examine the mechanisms underlying FGF10-induced tumourigenesis and explore novel approaches to target FGF10 signaling in cancer.

【 授权许可】

Unknown