Nanomotor‐Derived Porous Biomedical Particles from Droplet Microfluidics

Advanced Science

卷:9

Yuanjin Zhao¹  Cheng Zhao¹  Yi Cheng¹  Yuxiao Liu¹  Huan Wang² 

[1] Department of Rheumatology and Immunology Institute of Translational Medicine The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing 210008 China;

[2] State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China;

关键词: cell culture;    droplet;    microfluidics;    nanomotors;    porous microparticles;    wound healing;   

DOI  :  10.1002/advs.202104272

来源: DOAJ

【 摘 要 】

Abstract Porous particles have found widespread applications in therapeutic diagnosis, drug delivery, and tissue engineering due to their typical properties of large surface area, extensive loading capacity, and hierarchical microstructures. Attempts in this aspect are focusing on the development of effective methods to generate functional porous particles. Herein, a simple droplet microfluidics for continuously and directly generating porous particles by introducing bubble‐propelled nanomotors into the system is presented. As the nanomotors can continuously generate gas bubbles in the unsolidified droplet templates, the desirable porous microparticles can be obtained after droplet polymerization. It is demonstrated that the generation process is highly controlled and the resultant microparticles show excellent porosity and monodispersity. In addition, the obtained porous microparticles can serve as microcarriers for 3D cell culture, because of their characteristic porous structures and favorable biocompatibility. Moreover, owing to the existence of oxygen in these microparticles, they can be used to improve the healing effects of wounds in the type I diabetes rat models. These remarkable features of the generation strategy and the porous microparticles point to their potential values in various biomedical fields.

【 授权许可】

Unknown