Synthesis, antibacterial evaluation, in silico ADMET and molecular docking studies of new N-acylhydrazone derivatives from acridone

Arabian Journal of Chemistry

Adnane Aouidate¹  Mohammed Aarjane²  Amina Amine²  Siham Slassi³ 

[1] Corresponding author.;Laboratory of Chemistry/Biology Applied to the Environment, Faculty of Science, University Moulay Ismail, BP 11201 Zitoune, Meknes, Morocco;Laboratory of Molecular Chemistry and Natural Substances, School of Sciences, Moulay Ismail University, Morocco;

关键词: Acylhydrazone;    Acridone;    Antibacterial;    Docking;    ADMET;   

DOI  :  

来源: DOAJ

【 摘 要 】

Novel N-acylhydrazone derivatives from acridone have been synthesized by condensation of acridone acetohydrazide and various aldehyde. The novel acylhydrazones were tested for their in-vitro antibacterial activity against human pathogenic strains. The MIC results indicate that compound 3f displayed high antibacterial potential against Pseudomonas putida with MIC = 38.46 µg/mL, which is very close to that obtained with the commercial antibiotic. The synthesized compounds were subjected for docking studies to understand the interaction of our compounds and transcriptional regulator enzyme of pseudomonas putida and DNA gyrase complex of Staphyloccocus aureus.

【 授权许可】

Unknown