Highly Efficient One‐Pot Solvent‐Free Synthesis of 2,5‐Disubstituted‐1,3,4‐Oxadiazole via BTI‐mediated Oxidation of N‐Acylhydrazone from Hydrazide and Aldehyde

Bulletin of the Korean Chemical Society

Hakwon Kim¹  Xinhao Yan¹  Kyung Tak Noh¹  Young Jun Park¹  Nam Hwi Hur¹  Kyu Hyung Lee⁴  Goeun Lee⁴  Byeongno Lee⁴  Hyeonjin Lee⁴ 

[1] Department of Applied Chemistry, Institute of Natural Science Kyung Hee University Gyeonggi‐Department of Bioinspired Science, Department of Chemistry and Nano Science Ewha Womans University Seoul 03706 Korea;Department of Chemistry Sogang University Seoul 04107 Korea;Do 17104 Korea

关键词: Solvent‐;    free;    1,3,4‐;    Oxadiazole;    N‐;    Acylhydrazone;    Ball‐;    mill;    [Bis(trifluoroacetoxy)iodo]benzene‐;    oxidation;   

DOI  :  10.1002/bkcs.11160

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

2,5‐Disubstituted‐1,3,4‐oxadiazoles are prepared in excellent yields (up to 97%) under totally solvent‐free conditions by the quantitative formation of N‐acylhydrazone from the reaction of ahydrazide with an aldehyde using a ball‐mill for 10 min at room temperature followed by oxidation with BTI at 80°C for 1h.

【 授权许可】

Unknown