Syzygium cumini leaf extract protects macrophages against the oxidized LDL-induced toxicity: A promising atheroprotective effect

Biomedicine & Pharmacotherapy

Luana Caroline Schüler¹  Andreza Fabro de Bem²  Nilda de Vargas Barbosa³  Gabriel Teixeira de Macedo³  João Luís Souza Vargas³  Sabrina Antunes Ferreira³  Matheus Mülling dos Santos³  Alessandro de Souza Prestes³ 

[1] Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88040900 Florianópolis, SC, Brazil;Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade de Brasília, Brasília, Brazil;Programa de Pós-graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Avenida Roraima, 1000, 97105–900 Santa Maria, RS, Brazil;

关键词: Plant extract;    Atherosclerosis;    Low density lipoprotein;    Reactive species;    J774 macrophages;   

DOI  :  

来源: DOAJ

【 摘 要 】

Oxidized LDL (oxLDL) plays a pivotal role on atherosclerosis development, mainly in the formation of lipid-laden macrophage “foam cells”. As a consequence, substances that can modulate LDL oxidation have a pharmacological and therapeutic relevance. Based in previous findings showing the ability of Syzigium cumini leaf extract (ScExt) in preventing LDL oxidation in vitro, this study was aimed to assess the effects of ScExt on oxLDL-mediated toxicity in murine J774 macrophages-like cells. For biochemical analyses, LDL isolated from fresh human plasma and oxidized with CuSO4 was incubated with ScExt pre-treated macrophages. Our results demonstrated that ScExt was efficient in preventing the overproduction of reactive oxygen/nitrogen species (ROS/RNS), the loss of macrophage’s viability and the foam cells formation induced by oxLDL. These protective effects of ScExt make it a promising antioxidant for future trials toward atherogenesis.

【 授权许可】

Unknown