Unripe Musa sapientum peel in the healing of surgical wounds in rats

Acta Cirúrgica Brasileira

Lydia Masako Ferreira¹  Luis Eduardo Felipe Abla¹  Dênia Amélia Novato Castelli Von Atzingen¹  Alfredo Gragnani¹  Daniela Francescato Veiga¹  Lorraine Lorene Felix Cardoso²  Thiago Ricardo²  Adriana Rodrigues dos Anjos Mendonça² 

[1] Universidade Federal de São Paulo;Universidade do Vale do Sapucaí;

关键词: Musa sapientum;    Wound Healing;    Phytotherapy;    Rats;   

DOI  :  10.1590/S0102-86502013000100006

来源: DOAJ

【 摘 要 】

PURPOSE: To assess the effects of unripe Musa sapientum peel on the healing of surgical wounds in rats. METHODS: One hundred and twenty Wistar rats were divided into two treatment groups of 60 animals each: the control group (gel without the active ingredient) and experimental group (4% Musa sapientum peel gel). A 4 x 4 cm surgical wound was created on the back of each animal. The wound was cleaned daily with 0.9% saline, treated with 4% gel or natrosol gel (control), and covered with gauze. Animals from both groups were sacrificed after seven, 14 and 21 days of treatment; the tissue from the wound site was removed together with a margin of normal skin for histological analysis. RESULTS: No significant differences in wound contraction rates (p=0.982) were found between time points (seven, 14 and 21 days of treatment) in both groups. However, a significantly higher wound contraction rate was observed in the control group on day 21 compared with the experimental group (p=0.029). There were no significant differences in histomorphological features between groups. The experimental group showed an increased number of polymorphonuclear cells on day 7, with a significant reduction on day 21 (p=0.026). CONCLUSION: The use of 4% unripe Musa sapientum peel gel on surgical wounds in rats resulted in an increased number of polymorphonuclear cells on day 7, reduced wound contraction, reduced vascular proliferation and increased concentration of collagen fibers on day 21.

【 授权许可】

Unknown