Repair of surgical wounds in rats using a 10% unripe Musa sapientum peel gel

Acta Cirurgica Brasileira

Dênia Amélia Novato Castelli Von Atzingen¹  Adriana Rodrigues Dos Anjos Mendonça¹  Marcos Mesquita Filho¹  Vinícius Alves Alvarenga¹  Vinícius Almeida Assis¹  Afonso Esteves Penazzo¹  Julio Henrique Muzetti¹  Thaisa Sousa Rezende¹ 

关键词: Wound Healing;    Skin;    Musa sapientum;    Models;    Animal;    Rats;   

DOI  :  10.1590/S0102-865020150090000001

来源: SciELO

【 摘 要 】

PURPOSE:To investigate the efficacy of a 10% gel of unripe banana (Musa sapientum) peel in treating surgical wounds in rats.METHODS:A longitudinal, prospective, randomized triple-blind study was conducted with 60 Wistar rats (Rattus norvegicus albinus) weighing approximately 400g. The animals were randomly divided into: control group (treated with gel containing no active ingredient) and study group (treated with 10% gel of unripe banana peel). The gel was applied every three days to a 4x4-cm surgical wound created on the back of each animal (day 0) in both groups. Tissue samples were collected for histological analysis on days 14, 21 and 28.RESULTS:On day 14, more extensive vascular proliferation (p=0.023), presence of mononuclear cells (p=0.000), fibroblast proliferation (p=0.012), re-epithelialization (p=0.000), and decreased presence of polymorphonuclear cells (p=0.010) were observed in the study group than in controls. No significant between-group difference in the presence of polymorphonuclear cells was found on day 21. Fibroblast proliferation was significantly greater (p=0.006) in the study group than in the control group on day 28.CONCLUSION:The 10% gel of unripe banana peel showed anti-inflammatory activity and stimulated wound healing in rat skin when compared with a gel containing no active ingredient.

【 授权许可】

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