Acta Cirurgica Brasileira | |
Repair of surgical wounds in rats using a 10% unripe Musa sapientum peel gel | |
Dênia Amélia Novato Castelli Von Atzingen1  Adriana Rodrigues Dos Anjos Mendonça1  Marcos Mesquita Filho1  Vinícius Alves Alvarenga1  Vinícius Almeida Assis1  Afonso Esteves Penazzo1  Julio Henrique Muzetti1  Thaisa Sousa Rezende1  | |
关键词: Wound Healing; Skin; Musa sapientum; Models; Animal; Rats; | |
DOI : 10.1590/S0102-865020150090000001 | |
来源: SciELO | |
【 摘 要 】
PURPOSE:To investigate the efficacy of a 10% gel of unripe banana (Musa sapientum) peel in treating surgical wounds in rats.METHODS:A longitudinal, prospective, randomized triple-blind study was conducted with 60 Wistar rats (Rattus norvegicus albinus) weighing approximately 400g. The animals were randomly divided into: control group (treated with gel containing no active ingredient) and study group (treated with 10% gel of unripe banana peel). The gel was applied every three days to a 4x4-cm surgical wound created on the back of each animal (day 0) in both groups. Tissue samples were collected for histological analysis on days 14, 21 and 28.RESULTS:On day 14, more extensive vascular proliferation (p=0.023), presence of mononuclear cells (p=0.000), fibroblast proliferation (p=0.012), re-epithelialization (p=0.000), and decreased presence of polymorphonuclear cells (p=0.010) were observed in the study group than in controls. No significant between-group difference in the presence of polymorphonuclear cells was found on day 21. Fibroblast proliferation was significantly greater (p=0.006) in the study group than in the control group on day 28.CONCLUSION:The 10% gel of unripe banana peel showed anti-inflammatory activity and stimulated wound healing in rat skin when compared with a gel containing no active ingredient.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202005130101207ZK.pdf | 9167KB | download |