Gel from unripe Musa sapientum peel to repair surgical wounds in rats

Acta Cirurgica Brasileira

Dênia Amélia Novato Castelli Von Atzingen²  Alfredo Gragnani¹  Daniela Francescato Veiga¹  Luis Eduardo Felipe Abla¹  Adriana Rodrigues Dos Anjos Mendonça¹  Clayton Aparecido De Paula¹  Yara Juliano¹  José Carlos Correa¹  Marcio Raimundo De Faria¹  Lydia Masako Ferreira¹ 

[1] ,UNIFESPSao Paulo,Brazil

关键词: Musa sapientum;    Wound Healing;    Rats;    Musa sapientum;    Cicatrização;    Ratos;   

DOI  :  10.1590/S0102-86502011000500009

来源: SciELO

【 摘 要 】

PURPOSE: To determine the optimum concentration of a gel obtained from unripe banana (Musa sapientum) peel for wound treatment in rats. METHODS: A randomized triple blind study was conducted with 40 Wistar rats, which were divided into 4 groups: CG, control group; G2%, 2% gel concentration group; G4%, 4% gel concentration group; and G10%, 10 % gel concentration group. The banana peel gel was applied daily, for 7 days, to a 4-cm² wound created on the back of each animal of all groups. After this period, the wounds were biopsied. Statistical analysis was carried out using the Kruskal-Wallis test complemented by the Student-Newman-Keuls test. RESULTS: Macroscopic examination revealed that partial epithelialization occurred in all groups. Wound contraction was also observed in all groups and ranged from 1.38 to 1.57 mm in the study groups, and from 1.03 to 1.10 mm in the control group, with significant differences (p < 0.05) between the groups: CG and G10%, G2% and G4%, G2% and G10%. The interquartile deviation was smaller between the groups CG and G4%. CONCLUSION: The 4% gel obtained from unripe banana peel (G4%) resulted in better epithelialization of wounds healed by secondary intention compared with other gel concentrations.

【 授权许可】

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