The Assertive Brain: Anterior Cingulate Phosphocreatine plus Creatine Levels Correlate With Self-Directedness in Healthy Adolescents

Frontiers in Psychiatry

卷:10

Massimo Molteni¹  Maria Nobile¹  Cinzia Bressi²  Letizia Squarcina²  Paolo Brambilla²  Giuseppe Delvecchio³  Domenico Madonna³  Jeffrey A. Stanley⁴  Maddalena Mauri⁵  Sara Piccin⁶  Franco Fabbro⁶  Carolina Bonivento⁶  Marco Garzitto⁶  Barbara Tomasino⁶ 

[1] Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Italy;

[2] Department of Neurosciences and Mental Health, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy;

[3] Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy;

[4] Department of Psychiatry and Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, MI, United States;

[5] School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy;

[6] Scientific Institute, IRCCS Eugenio Medea, San Vito al Tagliamento, Italy;

关键词: magnetic resonance spectroscopy;    temperament character inventory;    adolescence;    brain biochemistry;    brain metabolism;   

DOI  :  10.3389/fpsyt.2019.00763

来源: DOAJ

【 摘 要 】

Despite various advances in the study of the neurobiological underpinnings of personality traits, the specific neural correlates associated with character and temperament traits are not yet fully understood. Therefore, this study aims to fill this gap by exploring the biochemical basis of personality, which is explored with the temperament and character inventory (TCI), during brain development in a sample of adolescents. Twenty-six healthy adolescents (aged between 13 and 21 years; 17 males and 9 females) with behavioral and emotional problems underwent a TCI evaluation and a 3T single-voxel proton magnetic resonance spectroscopy (1H MRS) acquisition of the anterior cingulate cortex (ACC). Absolute metabolite levels were estimated using LCModel: significant correlations between metabolite levels and selective TCI scales were identified. Specifically, phosphocreatine plus creatine (PCr+Cre) significantly correlated with self-directedness, positively, and with a self-transcendence (ST), negatively, while glycerophosphocholine plus phosphocholine (GPC+PC) and myo-inositol negatively correlated with ST. To the best of our knowledge, this is the first study reporting associations of brain metabolites with personality traits in adolescents. Therefore, our results represent a step forward for personality neuroscience within the study of biochemical systems and brain structures.

【 授权许可】

Unknown