Study Protocol for Teen Inflammation Glutamate Emotion Research (TIGER)

Frontiers in Human Neuroscience

Tiffany C. Ho¹  Amar Ojha²  Daniel M. Spielman³  Yael Rosenberg-Hasson⁴  Holden T. Maecker⁴  Manpreet K. Singh⁵  Rachel L. Weisenburger⁶  Johanna C. Walker⁶  Jillian R. Segarra⁶  Artenisa Kulla⁶  Giana I. Teresi⁶  Ian H. Gotlib⁶  Lucinda Sisk⁷  Meng Gu⁸ 

[1] 0Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, United States;Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, United States;Department of Electrical Engineering, Stanford University, Stanford, CA, United States;Department of Microbiology and Immunology, Stanford University, Stanford, CA, United States;Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States;Department of Psychology, Stanford University, Stanford, CA, United States;Department of Psychology, Yale University, New Haven, CT, United States;Department of Radiology, Stanford University, Stanford, CA, United States;Human Immune Monitoring Center, Stanford University, Stanford, CA, United States;Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, United States;

关键词: adolescence;    depression;    anterior cingulate cortex;    magnetic resonance spectroscopy;    glutamate;   

DOI  :  10.3389/fnhum.2020.585512

来源: DOAJ

【 摘 要 】

This article provides an overview of the study protocol for the Teen Inflammation Glutamate Emotion Research (TIGER) project, a longitudinal study in which we plan to recruit 60 depressed adolescents (ages 13–18 years) and 30 psychiatrically healthy controls in order to examine the inflammatory and glutamatergic pathways that contribute to the recurrence of depression in adolescents. TIGER is the first study to examine the effects of peripheral inflammation on neurodevelopmental trajectories by assessing changes in cortical glutamate in depressed adolescents. Here, we describe the scientific rationale, design, and methods for the TIGER project. This article is intended to serve as an introduction to this project and to provide details for investigators who may be seeking to replicate or extend these methods for other related research endeavors.

【 授权许可】

Unknown