Secondary Metabolites from the Deep-Sea Derived Fungus Acaromyces ingoldii FS121

Molecules

卷:21

Yu-Zhi Tan¹  Xiao-Wei Gao²  Yu-Chan Chen²  Zhang-Hua Sun²  Wei-Min Zhang²  Hong-Xin Liu² 

[1] College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China;

[2] State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China;

关键词: Acaromyces ingoldii;    secondary metabolites;    deep-sea derived fungus;    cell growth inhibition;   

DOI  :  10.3390/molecules21040371

来源: DOAJ

【 摘 要 】

Activity-guided isolation of the fermentation broth of the deep-sea derived fungus Acaromyces ingoldii FS121, which was obtained from the China South Sea, yielded a new naphtha-[2,3-b]pyrandione analogue, acaromycin A (1) and a new thiazole analogue, acaromyester A (2), as well as the known compound (+)-cryptosporin (3). Their structures, including absolute configurations, were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) spectra. Compounds 1–3 were evaluated for in vitro growth inhibitory activities against four tumor cell lines (MCF-7, NCI-H460, SF-268 and HepG-2), wherein compounds 1 and 3 exhibited considerable growth inhibitory effects, with IC50 values less than 10 µM.

【 授权许可】

Unknown