Highly Substituted Benzophenone Aldehydes and Eremophilane Derivatives from the Deep-Sea Derived Fungus Phomopsis lithocarpus FS508

Marine Drugs

Xiao-Xia Gao¹  Hai-Bo Tan²  Jian-Lin Xu³  Yu-Chan Chen³  Hao-Hua Li³  Zi-Lei Huang³  Wei-Min Zhang³  Sai-Ni Li³  Hong-Xin Liu³  Heng Guo³  Li-Qiong Xu³ 

[1] College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China;Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China;

关键词: deep-sea derived fungus;    Phomopsis lithocarpus;    benzophenone derivatives;    eremophilane derivative;   

DOI  :  10.3390/md16090329

来源: DOAJ

【 摘 要 】

Five new benzophenone derivatives named tenellones D–H (1–5), sharing a rare naturally occurring aldehyde functionality in this family, and a new eremophilane derivative named lithocarin A (7), together with two known compounds (6 and 8), were isolated from the deep marine sediment-derived fungus Phomopsis lithocarpus FS508. All of the structures for these new compounds were fully characterized and established on the basis of extensive spectroscopic interpretation and X-ray crystallographic analysis. Compound 5 exhibited cytotoxic activity against HepG-2 and A549 cell lines with IC50 values of 16.0 and 17.6 μM, respectively.

【 授权许可】

Unknown