Diversity Oriented Design of Various Benzophenone Derivatives and Their in Vitro Antifungal and Antibacterial Activities

Molecules

Li Sun¹  Jie Wu¹  Min Luo¹  Xiaoli Wang¹  Man Pan¹  Zhaopin Gou¹ 

[1] Marine College, Shandong University, Weihai Wenhua West Road, No.180, Weihai 264209, China

关键词: benzophenone derivatives;    bioactivity;    phytopathogenic fungi;    vibrio;   

DOI  :  10.3390/molecules16119739

来源: mdpi

【 摘 要 】

A series of new substituted benzophenone derivatives was designed, synthesized and screened for their antifungal and antibacterial activities. The bioassays indicated that most of the synthesized compounds showed some antifungal activity against the tested phytopathogenic fungi, but lower antibacterial activities towards the five vibrios isolated from marine sources. The preliminary structure activity relationship (SAR) of the compounds was also discussed.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.