Potential Effects of Chrysin on MDA-MB-231 Cells

International Journal of Molecular Sciences

Teh Ban Hong¹  Anizah Rahumatullah¹  Thaneswary Yogarajah¹  Maimunah Ahmad¹ 

[1] Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 USM, Penang, Malaysia; E-Mails:

关键词: chrysin;    cell growth inhibition;    lipid accumulation;    apoptosis;    PPAR mRNA expression;    ER-negative breast cancer;   

DOI  :  10.3390/ijms11031057

来源: mdpi

【 摘 要 】

This study aims to elucidate the effects of chrysin on human ER-negative breast cancer cell line, MDA-MB-231. The study demonstrated that treatment of MDA-MB-231 cells with 20 μM chysin for 48 h significantly inhibited the growth of MDA-MB-231 cells and induced cytoplasmic lipid accumulation in the cells, but that the observed of cell death was not caused by apoptosis. The expression of PPARalpha mRNA in chrysin-treated MDA-MB-231 cells was significantly increased, which was likely associated to the proliferation of the cells post chrysin treatment.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.