International Journal of Molecular Sciences | |
Potential Effects of Chrysin on MDA-MB-231 Cells | |
Teh Ban Hong1  Anizah Rahumatullah1  Thaneswary Yogarajah1  Maimunah Ahmad1  | |
[1] Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 USM, Penang, Malaysia; E-Mails: | |
关键词: chrysin; cell growth inhibition; lipid accumulation; apoptosis; PPAR mRNA expression; ER-negative breast cancer; | |
DOI : 10.3390/ijms11031057 | |
来源: mdpi | |
【 摘 要 】
This study aims to elucidate the effects of chrysin on human ER-negative breast cancer cell line, MDA-MB-231. The study demonstrated that treatment of MDA-MB-231 cells with 20 μM chysin for 48 h significantly inhibited the growth of MDA-MB-231 cells and induced cytoplasmic lipid accumulation in the cells, but that the observed of cell death was not caused by apoptosis. The expression of PPARalpha mRNA in chrysin-treated MDA-MB-231 cells was significantly increased, which was likely associated to the proliferation of the cells post chrysin treatment.
【 授权许可】
CC BY
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190054433ZK.pdf | 293KB | download |